|
|
|
|
|
Mini-Symposia
Session II
Wednesday,
October 3
|
Cytokines
and Cytokine Receptors as Targets for Therapy
Chaired by Rachel Caspi, NEI
2:00 p.m. to 3:30 p.m.
Natcher
Conference Center
Main Auditorium
Since
the discovery of interferons, cytokines have been
demonstrated to play a fundamental role in regulating
immune system development, maturation and function.
The discovery of specific cytokine receptors has led
to the elucidation and dissection of specific signal
transduction pathways whose activation results in
distinct changes in gene expression and cellular function.
Activation of these pathways affects the host response
in ways that are now becoming more completely understood.
This mini-symposium will explore the connection between
our understanding of the biochemical and molecular
mechanisms of cytokine action and the specific host
response to disease. Based on this knowledge, strategies
for disruption of the cytokine-cytokine receptor pathway
and the consequences of this intervention on disease
progression will be presented.
| Program |
|
| Tom
Waldmann, NCI |
Contrasting
Roles of IL-2 and IL-15 in the Life and Death
of Lymphocytes: Implications for Immunotherapy |
| Robert
Nussenblatt, NEI |
Bench
to Bedside: Targeting the IL-2 Receptor as Therapy
for Autoimmune Uveitis |
| Tom
Wynn, NIAID |
IL-13 Blockade and Treatment
of Infection-induced Liver Fibrosis |
| Warren
Strober, NIAID |
Treatment of Th1 Inflammations
with Anti-IL-12 and TGF-b |
|
Murine Models of Genetic Bone
Disease
Chaired by Joan Marini, NICHD
2:00 p.m. to 3:30 p.m.
Natcher
Conference Center
Balcony A
Bone
is a dynamic connective tissue, characterized by lifelong
remodeling and responsiveness to hormonal influences.
Disruptions in the structural molecules of bone matrix,
in cellular functions, or in housekeeping enzymes
can lead to clinical disorders. This mini-symposium
will highlight the advances made in understanding
the etiology and mechanisms of genetic bone disorders
by the use of mouse models. These animals also provide
valuable models to test disease treatments.
| Program |
|
| Antonella
Forlino, NICHD |
The
Brtl Mouse: A Murine Model for Osteogenesis Imperfecta |
| Kenn
Holmbeck, NIDCR |
MT1-MMP
Is An Essential Tool in Connective Tissue Housekeeping |
| Pamela
L. Schwartzberg, NHGRI |
Src Family Kinases in Osteoclast
Function |
| Marian
F. Young, NIDCR |
Small Leucine Rich Proteoglycan
KO Mice: New Models for Osteoporosis, Osteoarthritis
and Ectopic Calcification |
|
Regulatory
T cells
Chaired by Ethan M. Shevach, NIAID
2:00 p.m. to 3:30 p.m.
Natcher
Conference Center
Balcony B
Some
self-reactive T cells escape mechanisms of central
tolerance and exist in the periphery under the control
of thymic-derived regulatory T cells. One population
of these regulatory T cells can be readily identified
by the co-expression of CD4 and CD25. Deletion of
CD4+ CD25+ T cells results in the development of organ-specific
autoimmunity. Other studies have demonstrated the
existence of a distinct population of regulatory T
cells that mediate their function by secretion of
suppressive cytokines. While regulatory or suppressor
T cells may be beneficial to the control of autoimmune
disease, excess regulatory cell function may be harmful
in the generation of immunity to tumor associated
antigens or to infectious agents. Manipulation of
regulatory T cell function remains an important goal
for future studies.
| Program |
|
| Ethan
M. Shevach, NIAID |
Introduction |
| Rebecca
McHugh, NIAID |
Control
of Organ-specific Autoimmunity by CD4+CD25+ T
cells |
| Yasmine
Belkaid, NIAID |
Role of Regulatory T cells
in Persistent Infection by L. Major |
| Roland Martin,
NINDS |
Modulation of Autoreactive
T cell Function in Inflammatory Diseases of the
Central Nervous System |
|
Regulatory
RNAs
Chaired by Susan Gottesman, NCI, and Gisela Storz,
NICHD
2:00 p.m. to 3:30 p.m.
Natcher
Conference Center
Balcony C
RNA
not only serves as a structural element of ribosomes
and tRNA, as message, or as a component of ribozymes.
It is becoming increasingly clear that a variety of
RNAs play critical regulatory roles in the cell, including,
in addition to splicing, mediating positive and negative
translational regulation and modulation of the activity
of regulatory proteins. Some of the recent findings
on small RNA regulators and their modes of interaction
with protein cofactors and targets will be discussed.
| Program |
|
| Susan
Gottesman, NCI |
Introduction |
| Eric
Masse, NCI |
A
Small RNA Regulator of Intracellular Fe Use |
| Gisela
Storz, NICHD |
The Sm-like Hfq Protein Increases
OxyS Small RNA Interaction with Target mRNAs |
| Traci
Hall, NIEHS |
Crystal Structure of a PUMILIO
RNA-binding Domain |
| Brenda
Peculis, NIDDK |
The Process of Processing:
snoRNPs and Their Roles in Ribosome Biogenesis |
|
Cancer
Vaccines
Chaired by Larry W. Kwak, NCI
2:00 p.m. to 3:30 p.m.
Natcher
Conference Center
Conference Room E1/E2
Recent
developments in T cell biology and molecular biology
have fueled a renewed interest in cancer vaccines.
Proof of the scientific principle that sustained tumor
immunity can be elicited in hosts with established
tumors is rapidly being demonstrated in both solid
tumors and hematologic malignancies. This mini-symposium
will focus on recent advances in both experimental
models and clinical trials of human patients and on
the translational potential of newly developed vaccine
approaches. From the completion of the human genome
project, a large number of new tumor antigens are
sure to emerge as potential candidates for future
vaccine development.
| Program |
|
| Larry
W. Kwak, NCI |
Introduction |
| Jay
A. Berzofsky, NCI |
Cytokines
Regulating the CTL Response: A Push-Pull Approach
to Cancer Immunotherapy |
| Arya
Biragyn, NCI |
Proinflammatory Chemotactic
Factors of Innate and Adaptive Immunity Elicit
Efficient Anti B Cell Lymphoma Immunity When Used
to Target Tumor Antigens to APC |
| Steven
R. Rosenberg, NCI |
The Development of Immunotherapy
for Patients with Melanoma |
|
Understanding
Multi-functional Proteins"
Chaired by David Levens, NCI
2:00 p.m. to 3:30 p.m.
Natcher
Conference Center
Conference Room F1/F2
Examples
of multi-functional proteins possessing activities
residing in separable or overlapping domains are known.
The smaller than expected number genes in the mammalian
genome might indicate that multi-functionality is
more common than previously supposed. How do we think
about these molecules? Are they the result of evolutionary
happenstance or have they evolved as well-placed regulators
occurring at nodes in important pathways?
| Program |
|
| David
Levens, NCI |
Introduction |
| Joram
Piatigorsky, NEI |
Dual
Roles for Enzymes, Stress Proteins, and Gelsolin:
Lens
Crystallins and Abundant Corneal Proteins |
| Tracey
Rouault, NICHD |
Iron Regulatory Protein 1:
A functional Cytosolic Aconitase or RNA Binding
Protein Speculations on How Proteins Acquire Several
Distinct Roles |
| Eugene
V. Koonin, NCBI/NLM |
Multidomain Architectures and
Multiple Functions in Proteins: A Computational
Biologist's Perspective |
|
|
|
|
 |
