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Mini - Symposia

Mini-Symposia Session I
Wednesday, October 3


Molecular Imaging
Chaired by Robert S. Balaban, NHLBI

11:00 a.m. to 12:30 p.m.
Natcher Conference Center
Main Auditorium

This symposium is devoted to the discussion of molecular imaging in basic molecular biology as well as clinical medicine. The scope of molecular imaging from cells to animal models to clinical conditions will be reviewed. Techniques including magnetic resonance, confocal microscopy, and radioactive isotope approaches will be highlighted.

Program  
Alan Koretsky, NINDS Anatomical, Functional and Molecular MRI of the Brain
Jennifer Lippincott-Schwartz, NICHD Analysis of Secretory Protein Trafficking in Living Cells
Ronald Neumann, CC Pinpointing Proteins with Positrons
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Contemporary Flow Cytometry: Analysis of Lymphocyte Function
Chaired by Mario Roederer, VRC/NIAID

11:00 a.m. to 12:30 p.m.
Natcher Conference Center
Balcony A

The power of flow cytometry to resolve heterogeneity in the immune system is unique. The most prevalent application of flow cytometry has been to resolve leukocyte subsets based on cell surface protein expression patterns. However, more researchers are turning to this technology to provide detailed information about the functional repertoire of cells. This session will cover several different types of functional measurements made by flow cytometry that provide a much more detailed understanding of the roles of various cell types in immune function--combining the power of immunophenotyping to identify distinct subsets together with functional measurements to provide a cell-by-cell analysis of the immune system.

Program  
Calman Prussin, NIAID High Fidelity Analysis of T cell Cytokine Responses Using Intracellular Staining
Stephen De Rosa, VRC/NIAID Subsets of gamma delta T cells Identified and Functionally Characterized Using 11-color Flow Cytometry
Ronald Rabin, CBER/FDA Use of Flow Cytometry to Measure Responses to Chemokines
Richard Siegel, NIAMS FRET with GFP's: Visualizing Protein-Protein Interactions with Flow Cytometry
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Mitosis and Meiosis
Sponsored by the Cell Cycle Interest Group
Chaired by Mary Lilly, NICHD, and Orna Cohen-Fix, NIDDK

11:00 a.m. to 12:30 p.m.
Natcher Conference Center
Balcony B

The mitotic and meiotic divisions present many similar challenges of the cell. During both divisions multiple events must be coordinated to insure accurate chromosome segregation and division of cellular components. The failure to do so may lead an imbalance in the chromosome number as observed in Down Syndrome and certain types of cancer. This session will focus on the processes that govern progression through meiosis and mitosis, including chromosome cohesion and condensation, spindle dynamics and checkpoint control. Both shared and unique features of meiosis and mitosis will be discussed.

Program  
Michael Lichten, NCI Starting and Finishing Meiotic Recombination
Mel Depamphillis, NICHD Regulation of Eukaryotic DNA Replication through the Cell Cycle Dependent Binding and Release of Origin Recognition Proteins
Alexander Strunnikov, NICHD Cohesin, Condensin and Mitotic Chromosome Structure
Monica Murakami, NCI Cell Cycle Regulation is Required for Normal Gastrulation in Vertebrates
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Mouse Embryogenomics: Frontiers of Developmental Biology and Genomics
Chaired by Minoru Ko, NIA, and Colin Stewart, NCI

11:00 a.m. to 12:30 p.m.
Natcher Conference Center
Balcony C

The mouse model is increasingly valuable for the understanding of human biology and disease. Recent advancements in genomics, including the availability of complete genome sequences for human and mouse, have made approaches even more powerful. This mini-symposium will review state-of-the-art methodologies in the context of developmental biology, genetics, and genomics of the mouse.

Program  
Neal G. Copeland, NCI Recombineering Provides a Powerful New Tool for Functional Genomic Studies in Mouse
William J. Pavan, NHGRI Functional Genomic Analysis of Neural Crest Development
Mark Lewandoski, NCI Controlling Gene Expression in Mice with DNA Recombinases
Minoru S. H. Ko, NIA Application of Mouse Embryonic cDNA Microarrays to Stem Cell Biology
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Molecular Targets in Cancer
Chaired by Allan M. Weissman, NCI

11:00 a.m. to 12:30 p.m.
Natcher Conference Center
Conference Room E1/E2

The ability to target proteins whose expression, structure, or cellular function is altered in tumors provides the opportunity to vastly expand the potential to specifically attack cancer cells. This session will focus on exciting ways in which molecular targeting of cancer cell proteins are being evaluated and applied using both small molecules and antibodies.

Program  
Ira Pastan, NCI Immunotoxin Therapy of Cancer
Len Neckers, NCI Molecular chaperones as novel anti-cancer targets: Lessons from geldanamycin and HSP90
Karen Vousden, NCI Reactivation of p53 by Inhibition of Mdm2 Ubiquitin Protein Ligase Activity
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Neural Immune Factors in Neurocognitive Effects and Toxicity of Chemotherapy
Chaired by Howard A. Fine, NCI/NINDS

11:00 a.m. to 12:30 p.m.
Natcher Conference Center
Conference Room F1/F2

Neurotoxicity is a broad term that pertains to damage to the peripheral and central nervous system (CNS) from either environmental and/or endogenous insults. Such insults include ionizing radiation and chemical toxins in the case of iatrogenic neurotoxicity, and infectious and immunologic processes in the case of endogenous mechanisms of neurotoxicity.

As our understanding of the cellular and molecular physiology of the CNS increases, it has become clear that proper neurological function requires a coordinated, and healthy functional relationship between neurons, glia, and vascular endothelium. Thus, different insults may affect different cell types or physiological processes within the CNS ultimately leading to neuronal dysfunction and loss, the common denominator of most neurotoxic mechanisms. Thus, the field of neurotoxicity has become an area of interest to scientists interested not only in neuroscience, but also infectious diseases and immune regulatory diseases. Now with growing evidence that cytokines and hormonal therapy can cause acute neurotoxicity, and both radiation therapy and chemotherapy can cause significant long term neurocognitive toxicity in both children and adults, investigators interested in cancer therapy have also become interested in issues related to damage to the CNS.

This symposium will bring together investigators who study different clinical models of damage to the CNS in an initial attempt to stimulate interest in a NIH-wide initiative to better understand the molecular, cellular, and clinical mechanisms of neurotoxicity and to begin to devise strategies to circumvent this devastating condition.

Program  
Roland Martin, NINDS Modulation of Immune Function by the Antidepressant Rolipram, a Phosphodiesterase Type 4 Inhibitor
Philip Tofilon, NCI Radiotherapy-induced CNS Toxicity: A Dynamic Process
Adriana Marques, NIAID Autoimmunity and Lyme Disease
Kathy Warren, NCI Detecting Neurotoxicity in Children with Brain Tumors
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