Mitosis: From molecular detail to human disease

Wednesday, October 10, 2012 — Concurrent Symposia Session III
2:00 p.m. – 4:00 p.m.	Balcony B

Co-chairs

• Mary Dasso, NICHD
• Ji Luo, NCI

Program

Mitotic chromosome segregation is a fundamental process that assures genomic stability in all eukaryotes. Moreover, controlled cell division plays a key role in the specification of many cell fate choices and helps to govern the size, structure and shape of tissues. Mitotic defects cause human diseases, particularly cancers, and underlie some forms of infertility. This symposium will focus on the diverse range of novel approaches that are being developed throughout the NIH to understand this critical process, from mathematical modeling of regulatory circuits to the identification of therapeutic targets based upon mitotic deficiencies of cancer cells. (Four of these speakers are tenure-track investigators.)

Nuclear structure deformation during mitotic arrest in budding yeast
Orna Cohen-Fix, NIDDK

Mitotic RanGTP gradient promotes mitotic progression in normal and cancer cells and is amplified by chromosomal gain
Petr Kalab, NCI

Allele-specific mRNA and protein expression on genetic variants of CCNE1 associated with risk of bladder cancer FARE Award Winner
Indu Kohaar, NCI

Spatio-temporal regulation of checkpoints in mitosis
Jian Liu, NHLBI

The Ras synthetic lethal gene ERH controls chromosome congression and the splicing of the mitotic motor protein CENP-E
Ji Luo, NCI

Centrosome maturation in asymmetric divisions
Nasser Rusan, NHLBI

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