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Here, there, everywhere: The journey of nuclear receptors

Tuesday, October 09, 2012 — Concurrent Symposia Session I

3:00 p.m. – 5:00 p.m.

Conf. Room F


  • Gordon Hager, NCI
  • Kenneth Korach, NIEHS


From the isolation of steroid hormones decades ago, to the profiling of global interactions of nuclear receptors using next generation technologies, nuclear receptor mediated response has served as a critical focus that has greatly advanced understanding of molecular events underlying biological processes. Many of the critical advances have been within NIH intramural laboratories. This symposium will highlight recent research that has revealed interactions between chromatin and nuclear receptors at a molecular level in cells and tissues, which promises to pave the way to future advances in our understanding of these essential processes and dysfunctions leading to disease.

Histone modification in nuclear receptor transactivation: cause or consequence?

Whole-Genome estrogen receptor binding in mouse uterine tissue revealed by ChIP-Seq
Sylvia Hewitt, NIEHS

Mechanisms regulating genome wide recruitment of GR to chromatin in liver tissue
Lars Grontved, NCI

Proteasome activity and glucocorticoid receptor transcriptional mechanisms in breast cancer cells
Harriet Kinyamu, NIEHS

Dynamic chromatin transitions with complex lifetimes induced by glucocorticoid receptor
Diana Stavreva, NCI

Peroxisome proliferator-activated receptor (PPAR) gamma and G-protein coupled receptor 40 (GPCR40) function as an integrated two-receptor signaling pathway FARE Award Winner
Keytam Awad, CC

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