Quantitative biology at the single-cell level

Tuesday, October 09, 2012 — Concurrent Symposia Session I
3:00 p.m. – 5:00 p.m.	Conf. Room D

Co-chairs

• Eric Batchelor, NCI
• Myong-Hee Sung, NCI

Program

Advances in numerous areas of the biological and medical sciences will continue to require a quantitative understanding of the complex network of biochemical interactions underlying biological phenomena. Accurate analysis of such a network often requires probing interactions at the level of individual cells. Emerging single-cell technologies and methodologies are providing unprecedented opportunities to better understand a wide variety of biological processes. Such insight is important not only for a basic understanding of cell biology, but also for providing new therapeutic avenues for treating a wide range of diseases, including cancer, immune disorders, and neurological diseases. This symposium will highlight the research of experts from the intramural program who develop and use various cutting-edge single-cell technologies including super-resolution microscopy, high-content imaging, and dynamical network analysis. Their research illustrates how these new quantitative approaches are being used to tackle a diverse range of biomedical questions.

High-content imaging analysis of pathogen-sensing systems
Iain Fraser, NIAID

Sharper and faster: new imaging technologies for cells and embryos
Hari Shroff, NIBIB

NF-kappaB dynamics on multiple timescales by live cell imaging
Myong-Hee Sung, NCI

Testing in silico predictions of p53 dynamics by direct measurements of transcription kinetics
Sohyoung Kim, NCI

A role for actin arcs in the advance of migrating cells
Dylan Burnette, NIGMS

Coordination of mitochondrial activity across the rat salivary glands epithelium imaged by intravital two-photon microscopy FARE Award Winner
Natalie Porat Shilom, NIDCR

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