Stem cells in development and diseases

Wednesday, October 10, 2012 — Concurrent Symposia Session III
2:00 p.m. – 4:00 p.m.	Kirschstein Auditorium

Chair

• Steven Hou, NCI

Program

Tissues and organs in animals are generated and maintained by stem cells, which possess the potential for unlimited self-renewal. Through asymmetric cell division, a stem cell in adult tissues can produce one daughter cell whose self-renewing progeny maintain the stem-cell population and a second daughter cell that will give rise to one or many differentiated and short-lived cell types that will replace damaged or dying cells. Similarly, tumors may originate from a few transformed cells with stem-cell characteristics, called cancer stem cells. Stem cells have immense potential for therapeutic use in regenerative medicine and as targets for anticancer therapies. To make use of this potential, we must first understand the molecular parameters that define a stem cell and the mechanisms that regulate stem-cell behavior. This symposium will bring together NIH experts working on basic stem cell biology and stem cell-related diseases.

Kit and Fgfr2b regulate progenitor cell expansion during organogenesis
Matthew Hoffman, NIDCR

Stem cell regulation in drosophila intestine
Steven Hou, NCI

Microenvironment in the regulation of hair follicle stem cells
Isaac Brownell, NCI

mTor signaling and epithelial stem cell regulation
Ramiro Iglesias-Barthomew and Silvio Gutkind, NIDCR

In vitro generation of human cells with cancer stem cell properties
Paola Scaffidi and Tom Misteli, NCI

Tumor suppressor p15Ink4b determines cell fate of hematopoietic progenitors: Implications for development of human blood disorders FARE Award Winner
Rita Humeniuk, NCI

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