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Matrix biology and matrix remodeling

Wednesday, October 10, 2012 — Concurrent Symposia Session III

2:00 p.m. – 4:00 p.m.

Conf. Room D


  • Keir Neuman, NHLBI


Extra-cellular matrices provide the structural underpinning of human form and function. Cells comprising human tissues are embedded in, and supported by, extracellular matrices composed of collagens, proteoglycans, and associated proteins. Mineralized matrices form the basis for the skeletal system, including cartilage and teeth. Matrix scaffolds are deposited and remodeled by resident cells providing an organized milieu that in turn exerts multiple effects on cell activity, including differentiation and migration. Physiological processes including development, morphogenesis, and wound healing are associated with matrix formation and remodeling. Pathologies including atherosclerosis, metastatic invasion and rheumatoid arthritis are associated with misregulation of remodeling, whereas bone and connective tissue disorders are associated with matrix protein mutations. This symposium will bring together NIH investigators from diverse research areas who share a common interest in the extra cellular matrix and how it is remodeled.

Matrix regulation of signaling, cell migration, and development
Kenneth Yamada, NIDCR

Exome sequencing and association analysis implicates extracellular matrix gene, FBN2 in early and late onset macular degenerations FARE Award Winner
Rinki Ratna Priya, NEI

Procollagen folding and misfolding in the cell
Sergey Leikin, NICHD

Understanding the abnormal trafficking of mutant DSPP in dentin diseases suggests a new class of cargo receptor(s) for exiting the endoplasmic reticulum
Larry W. Fisher, NIDCR

The sour side of sugars: Overcoming chondroitin sulfate proteoglycans to promote axonal regeneration in the CNS
Herbert Geller, NHLBI

Single-molecule tracking of collagenase on native type I collagen fibrils reveals degradation mechanism
Keir C. Neuman, NHLBI

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