Translational research in addiction, stress, and anxiety

Wednesday, October 10, 2012 — Concurrent Symposia Session II
10:00 a.m. – Noon	Conf. Room E1/E2

Co-chairs

• Yavin Shaham, NIDA
• Andrew Holmes, NIAAA

Program

We will present translation research performed at NIAAA, NIDA, and NIMH. Holmes (NIAAA) will present mouse and human studies showing that pharmacological inhibition and genetic variation in an enzyme degrading the endocannabinoid anandamide promotes trauma recovery and predicts stress coping. Cameron (NIMH) will present rodent studies showing that inhibiting adult neurogenesis prolongs stress response and increases anxiety/depressive-like behavior. She will also show that ketamine, a rapidly-acting antidepressant, could act via new neurons. Grillon (NIMH) will present rat and human studies on functional dissociation between fear and anxiety. He will then discuss the implications of this dissociation for clinical anxiety research. Shaham (NIDA) will present rat studies using the reinstatement model that have inspired human studies on the effect of pharmacological and learning manipulations on drug craving. Heilig (NIAAA) will present mouse, rat, monkey, and human studies supporting a ‘kindling’ process, controlled in part by genetic susceptibility, which promotes alcoholism. The implications of these studies to personalized alcoholism treatment are discussed.

Development and field demonstration of software for delivery of contingency management - an empirically supported behavioral treatment for addiction FARE Award Winner
Michelle Jobes, NIAAA

Convergent translational support for the role of endocannabinoids in processing fear and stress
Andrew Holmes, NIAAA

New neurons in the adult dentate gyrus buffer stress response and anxiety/depression-like behavior
Heather Cameron, NIMH

Distinguishing anxiety from fear: from basic science to clinical studies
Christian Grillon, NIMH

Translational research based on the reinstatement model of drug relapse: recent progress
Yavin Shaham, NIDA

Pharmacogenetics and the role of stress for excessive alcohol intake
Markus Heilig, NIAAA

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