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The Protein Chemistry Laboratory at Frederick National Laboratory for Cancer Research

Thursday, October 11, 2012 — Poster Session III

10:00 a.m. – Noon

Natcher Conference Center, Building 45

NCI

TECH-1

Authors

  • L Bindu
  • K Worthy
  • Y Kim
  • S Colantonio
  • O Chertov
  • A Stephen

Abstract

The Protein Chemistry Laboratory (PCL) in the Advanced Technology Program at Frederick National Laboratory for Cancer Research offers unparalleled capabilities in surface plasmon resonance (SPR) spectroscopy and fluorescence approaches for characterization of molecular interactions, and maintains complementary advanced protein chemistry techniques for protein identification including mass spectrometry (MS) and Edman sequencing. PCL has state-of-the art matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) MS with MALDI-imaging capabilities and a MALDI-TOF equipped with ultra-high mass detection. PCL also provides high-performance liquid chromatography (HPLC) purification and quality control of proteins and oligonucleotides. PCL has the capability to measure the metabolic flux in tissue culture cells. The objective of the laboratory is to provide service and work collaboratively with colleagues and help them achieve their research objectives.

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