October 9 - 12, 2012
Building 10 & Natcher Conference Center
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- Opening Plenary Session
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2011 program
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Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system
| Wednesday, October 10, 2012 — Poster Session II | |||
|---|---|---|---|
Noon – 2:00 p.m |
Natcher Conference Center, Building 45 |
NCI |
STRUCTBIO-4 |
Authors
- G.T. Lountos
- J.E. Tropea
- D.S. Waugh
Abstract
The Yersinia pestis YscD protein is an essential component of the type III secretion system. YscD consists of an N-terminal cytoplasmic domain (residues 1-121), a transmembrane linker (122-142) and a large periplasmic domain (143-419). Both the cytoplasmic and the periplasmic domains are required for the assembly of the type III secretion system. Here, the structure of the YscD cytoplasmic domain solved by SAD phasing is presented. Although the three-dimensional structure is similar to those of forkhead-associated (FHA) domains, comparison with the structures of canonical FHA domains revealed that the cytoplasmic domain of YscD lacks the conserved residues that are required for binding phosphothreonine and is therefore unlikely to function as a true FHA domain.
