Multifunctional nanoplatform for mesenchymal stem cells-mediated tumoritropic delivery

Thursday, October 11, 2012 — Poster Session III
10:00 a.m. – Noon	Natcher Conference Center, Building 45	NIBIB	IMAG-11

Authors

• X Huang
• F Zhang
• H Wang
• G Niu
• X Chen

Abstract

The monitoring of trafficking patterns of transplanted stem cells is vital to validate the therapeutic efficacy and safety. Although various noninvasive stem cell-tracking methods have been developed to follow the distribution and migration of transplanted stem cells in vivo, its clinical translation has continued to prove daunting. Recently, nanoparticles (NPs) have generated great interest as an ideal stem cell-tracking candidate by combining several kinds of imaging tags, such as fluorophores, magnetic resonance imaging (MRI) contrast agents and radioisotopes. However, each imaging modality has its own strengths and limitations. Herein, we developed a novel mesoporous silica-based triple-modal imaging nanoprobe (MSN-probe) that possesses the long-term imaging ability to noninvasive track the in vivo fate and tumor homing of stem cells. In this system, near-infrared dyes (ZW800), MRI contrast agents (Gd3+) and radioisotopes (64Cu) were integrated into one single mesoporous silica nanoparticle. As a model system, mesenchymal stem cells (MSCs) were labeled by MSN-probes and their migration and homing to tumors were investigated in a mouse U87 brain tumor model. The interdisciplinary approach taken by this research project, involving molecular imaging, nanomedicine and stem cell biology, will provide extensive new ideas for future stem cells studies.

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