Diabetes mellitus moderates the influence of dietary sodium on resting hemodynamics in African Americans but not Whites in the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Study

Thursday, October 11, 2012 — Poster Session III
10:00 a.m. – Noon	Natcher Conference Center, Building 45	NIA	EPID-16

Authors

• JM McNeely
• MA
• SR Waldstein
• PhD
• MF Kuczmarski
• PHD
• RD
• LDN
• MK Evans
• MD
• AB Zonderman
• PhD

Abstract

Hypertension is highly prevalent among African Americans (AA) and commonly coexists with insulin resistance. Excessive salt intake might be associated with the development of hypertension and insulin resistance. Here we examined relations of dietary sodium intake and diabetes to resting hemodynamics in 772 AA and White adults enrolled in the HANDLS Study. The sample had a mean age of 47.5 years, was 44% male, 61% AA, and 61% below 125% poverty status. Race stratified multiple regression analyses were computed separately for resting systolic blood pressure (SBP), diastolic BP (DBP), total peripheral resistance (TPR), stroke volume (SV), and cardiac output (CO) to determine whether diabetes moderates the influence of dietary sodium on resting hemodynamics differently in AA and Whites. For Whites, higher sodium intake was associated with higher SV (beta=0.24; p<.05) and lower TPR (beta=-0.18; p<.05). For AA with diabetes, higher sodium intake was associated with higher DBP (beta=0.27; p<.05), TPR (beta=0.321; p<.01) and lower CO (beta=0.24; p<.05). The results of this study indicate that diabetes moderates the influence of sodium intake on resting hemodynamics in AA but not Whites. Understanding racial differences in how insulin resistance moderates sodium intake could lead to effective interventions to control blood pressure in AA.

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