Elevated progesterone on the day of hCG administration negatively affects clinical pregnancy in both cleavage and blastocyst embryo transfers.

Thursday, October 11, 2012 — Poster Session III
10:00 a.m. – Noon	Natcher Conference Center, Building 45	NICHD	ENDOC-7

Authors

• MJ Hill
• KS Richter
• G Levy
• AH DeCherney
• ED Levens
• G Suthar
• E Widra
• MJ Levy

Abstract

Objective: To evaluate if elevated progesterone on the day of hCG is associated with poorer outcomes for both cleavage and blastocyst stage embryo transfers. Design: Retrospective cohort study. Patients: 1826 fresh autologous ART cycles. Interventions: Serum progesterone level on the day of hCG. Main outcome measures: Clinical pregnancy. Results: 1050 blastocyst and 776 cleavage stage ART cycles were evaluated. Progesterone values were not correlated with markers of oocyte or embryo quality to include fertilization, embryo stage at transfer, or embryos available for cryopreservation. Patient age, stage of embryo transfer, and progesterone level on the day of hCG were all significantly correlated to clinical pregnancy by multiple logistic regression analysis (p<0.0001 for all). Higher progesterone levels correlated with decreased clinical pregnancy for both cleavage and blastocyst stage embryos (p<0.0001). The non-significance of an interaction between progesterone level and stage of transfer (p=0.74) in the multiple regression model indicated that the relationship between progesterone and pregnancy outcomes was similar regardless of transfer stage. Conclusion: Elevated serum progesterone on the day of hCG is negatively correlated with clinical pregnancy in both cleavage and blastocyst stage transfers.

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