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Matched samples comparison of in vitro fertilization (IVF) clinical outcomes associated with Leuprolide Acetate (LA) versus human Chorionic Gonadotropin (hCG) trigger for oocyte maturation

Thursday, October 11, 2012 — Poster Session III

10:00 a.m. – Noon

Natcher Conference Center, Building 45




  • SA Beall
  • K Moon
  • E Widra
  • A DeCherney
  • F Chang


Objective: To determine whether IVF outcomes of patients triggered with LA are comparable to those triggered with hCG. Design: Retrospectively matched samples. Materials and Methods: Autologous IVF cycles with oocyte retrieval (OR) in 2010 were reviewed. Patients at high risk for ovarian hyperstimulation syndrome (OHSS) underwent a gonadotropin-releasing hormone (GnRH) antagonist protocol with LA trigger. Patients triggered with LA were matched for age and serum estradiol (E2) level on the day of trigger to patients triggered with hCG. Cycles with absent fertilization or immediate cryopreservation were excluded. Outcomes were compared by chi-square or t-test as appropriate. Results: Patients undergoing LA trigger had significantly more oocytes retrieved (16.5 vs 14.8, p<0.0001), percent mature oocytes (81% vs 78%, p=0.011), frequency blastocyst transfer (75% vs 64%, p<0.0001), surplus cryopreserved embryos (50% vs 44%, p=0.025), and fewer embryos per transfer (1.8 vs 2.0, p<0.0001). There were no significant differences in cycle cancelation (1.5% vs 1.9%, p=0.5), OHSS requiring paracentesis (0.9% vs 1.3%, p=0.6), fertilization rate (59.4% vs 57.3%, p=0.052), clinical pregnancy (54.2% vs 52.3%, p=0.5) or live birth (45.6% vs 45.1%, p=0.8). Conclusions: In patients at risk for OHSS, LA trigger is a safe and effective option with comparable outcomes to hCG.

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