October 9 - 12, 2012
Building 10 & Natcher Conference Center
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Two types of metabolic oscillations in pancreatic islets
| Thursday, October 11, 2012 — Poster Session III | |||
|---|---|---|---|
10:00 a.m. – Noon |
Natcher Conference Center, Building 45 |
NIDDK |
ENDOC-16 |
Authors
- M. Watts
- B. Fendler
- R. Bertram
- A. Sherman
Abstract
Diazoxide (Dz) hyperpolarizes pancreatic islets by abolishing calcium channel activation, thus terminating islet calcium oscillations. Resent experimental data shows that metabolic oscillations can persist without calcium oscillations by addition of Dz. It was also shown that in some cases, when the metabolic oscillations were eliminated with Dz, increasing the cytosolic calcium concentration by addition of KCl could restart the metabolic oscillations. So, why do metabolic oscillations persist in some islets and not others, and why does raising the cytosolic calcium concentration restart many of those oscillations? We answer these questions using the Dual Oscillator Model (DOM) of pancreatic islets. The DOM can reproduce the experiential data and shows that there are two different mechanisms for metabolic oscillations, those driven by calcium oscillations and those independent of them.
