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Genome-Wide RNAi screening at the NIH through the Trans-NIH RNAi Screening Facility

Thursday, October 11, 2012 — NIH Core Poster Session

10:00 a.m. – Noon

Building 10 South Lobby




  • S.E. Martin
  • E. Buehler
  • Y. Chen
  • R. Guha
  • C. Klummp
  • P. Tuzmen
  • N.J. Caplen
  • C.P. Austin


Gene silencing through RNAi has quickly emerged as a powerful tool for genetic loss of function studies. We have established a state-of-the-art RNAi screening facility, housed at NCGC, to serve the greater NIH research community. This facility has been fully operational since 2011 and dozens of projects underway from a variety of Institutes. Studies range from identifying genes that modulate the activity of cancer drugs to those that affect virus infectivity and replication. A major part of the RNAi Facility’s mission is to advance the science of RNAi screening. Towards this end we continue to develop and improve methods that identify and interpret off-target effects in RNAi screens, which represent the major obstacle in using this technology.

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