mAdb—microArray Database System: bioinformatics for analyzing and managing microarray data

Tuesday, October 09, 2012 — Poster Session I
1:00 p.m. – 3:00 p.m	Natcher Conference Center, Building 45	CIT	BIOINFO-1

Authors

• E Asaki
• Y He
• K Meyers
• W Xiao
• J Powell

Abstract

The microArray Database (mAdb), a Web-based NIH resource, allows researchers to analyze, explore and manage their own microarray data. Scientists can access this easy-to-use interface to evaluate the quality of their microarrays or use a variety of analytical approaches to decipher array data in a meaningful way. Though mAdb started over ten years ago by supporting in-house arrays printed at the NCI, NIAID and FDA microArray Core Centers, most submissions now originate from commercial arrays such as Affymetrix, Agilent and Illumina. We have standard statistical tools (e.g. t-test, ANOVA), but have also incorporated R/BioConductor tools, such as LIMMA (Linear Models for mircoArray data), SAM (Statistical Analysis of Microarrays) and GSEA (Gene Set Enrichment Analysis). Calculations are done on our servers, so a user does not need a powerful computer even for large datasets. Data and analysis output can be securely shared with collaborators or downloaded in a variety of formats for further analysis with local tools. Data are annotated with gene, location, ontology and pathway information and include links to external sites (e.g. NCBI, GO, KEGG and UCSC).

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