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Home > Concurrent Symposia Sessions > Emerging Therapeutic Targets in Neuroinflammation and Neurodegenerative Diseases

Concurrent Symposia Sessions

Wednesday, October 7, 2009
Natcher Conference Center
Symposia Session III
Balcony B

Emerging Therapeutic Targets in Neuroinflammation and Neurodegenerative Diseases
1:00 p.m. – 3:00 p.m.

Co-Chairs: Afonso Silva, NINDS and Francesca Bosetti, NIA

Neuroinflammation is a hallmark of many neurodegenerative diseases, such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. In the past few decades, significant effort has been placed on understanding the pathophysiology of neuroinflammation and on the development of novel drugs and therapies aimed at containing or inhibiting the neuroinflammatory chain of events contributing to neurodegeneration. However, the development of therapies focused on specific molecular targets, such as the cyclooxygenases (COX), has faced multiple and unexpected adverse effects. There is increasing evidence for a complex interaction between COX, reactive oxygen species (ROS), angiogenesis and multiple gene expression pathways that act in concert in the neuroinflammatory chain of events. Understanding the neuroinflammatory cascade at multiple levels may improve the specificity and efficacy of novel therapeutic approaches. The proposed symposium will describe recent studies elucidating differential roles of COX and ROS in neuroinflammation, the unintended effects of selective inhibitors of COX on modulating multiple gene expression pathways, and the interaction between neuroinflammation and angiogenesis. Data provided by these studies have a strong potential of identifying novel targets for therapy that may impact neurodegenerative diseases. Speakers are drawn from multiple institutes, offering a multi-faceted, broad view of the theme that is expected to attract wide interest and attendance.

Program

Presentation by FARE Award Winner
A Novel Function of Platelets in the Pathogenesis of Experimental Autoimmune Encephalomyelitis (EAE)
Harald Langer, NCI

Differential Roles of COX-1 and COX-2 in a Murine Model of Demyelination
Afonso C. Silva, NINDS

COX-1 and COX-2 Have Opposite Effects on Leukocyte Recruitment Into the Inflamed Brain via the PGE2 EP4 Receptor
Francesca Bosetti, NIA

Modulation of Multiple Gene Expression Pathways by Selective COX-2 Inhibitors in a Clinical Model of Acute Neuroinflammation
Raymond Dionne, NINR

Novel Insights into Vascular Cell Interactions and Vascular Inflammation in Experimental Autoimmune Encephalomyelitis
Trian Chavakis, NCI

Nox Family NADPH Oxidases: Diverse Reactive Oxygen Species (ROS) Generators in Innate and Adaptive Immune Responses
Thomas Leto, NIAID

The Spectrum of Autoinflammatory Diseases: Recent Bench-to-Bedside Observations
Raphaela Goldbach-Mansky, NIAMS

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