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Concurrent Symposia Sessions

Wednesday, October 7, 2009
Natcher Conference Center
Symposia Session II
Main Auditorium

Large-scale RNAi Screening for Gene Function Discovery
9:00 a.m. - 11:00 a.m

Co-Chairs: Natasha Caplen, NCI and Chris Austin, NCGC

Technologies that exploit the endogenous RNA-based gene silencing mechanism, RNA interference (RNAi), are now widely used to interrogate gene function. Increasingly RNAi technologies are also being applied in model organisms and mammalian cells on a larger scale for gene function discovery using a variety of screening approaches. This symposium will focus on large-scale RNAi screening approaches being used by NIH Scientists and will include discussion of a new Trans-NIH initiative to establish a high-throughput synthetic siRNA screening program.


Presentation by FARE Award Winner
Dissecting the Role of Mucin-type O-Glycosylation in Cell Adhesion and Morphology Using RNA Interference in Drosophila Cell Culture
Liping Zhang, NIDCR

Introduction to RNAi Screening
Natasha Caplen, NCI

Probing Lipid Homeostasis in Drosophila by Genome-wide RNAi
Brian Oliver, NIDDK

Application of shRNA-based RNAi Screening
Louis Staudt, NCI

Probing Innate Immune Signaling Networks with siRNA Screening
Iain Fraser, NIAID

The Trans-NIH RNAi Initiative
Scott Martin, NCGC and Chris Austin, NCGC

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