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Home > Concurrent Symposia Sessions > Finding Additional High-risk Susceptibility Genes: Problems and Solutions

Concurrent Symposia Sessions

Tuesday, October 6, 2009
Natcher Conference Center
Symposia Session I
Conference Room E1/E2

Finding Additional High-risk Susceptibility Genes: Problems and Solutions
2:00 p.m. – 4:00 p.m.

Chair: Alisa Goldstein, NCI

Although much attention is currently focused on genome-wide association studies and the detection of low-risk susceptibility genes, findings from diverse studies ranging from linkage and heritability evaluations to LOH/CGH and functional genomics examinations suggest that many high-risk susceptibility genes remain to be identified. Discovering these rare high-risk genes, however, has become more complicated. Incorporation of epidemiologic/clinical data and/or molecular genetic/functional genomics data plus enhancement of analytic strategies will help to increase power to identify additional high-risk susceptibility genes. This session will examine the current state of high-risk susceptibility gene identification and the challenges and opportunities to improve gene discovery.


Presentation by FARE Award Winner
Global Identification of Genes Haploinsufficient for Genomic Stability in
S. Cerevisiae
John Choy, NCI

Session Overview
Alisa Goldstein, NCI

Linkage Was Successful, So Why Can’t We Find a Gene? Examples from Cancer and Other Diseases
Joan Bailey-Wilson, NHGRI

Mendelian Loci and Quantitative Traits: Challenges and Opportunities
Alexander Wilson, NHGRI

Identification of Major Susceptibility Genes Using Combined Linkage and Array-CGH Analyses
Rose Yang, NCI

Next Generation Sequencing Approaches: Current Accomplishment(s) and Future Directions
Jim Mullikin, NHGRI

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