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Concurrent Symposia Sessions

Wednesday, October 7, 2009
Natcher Conference Center
Symposia Session II
Balcony A

Cross-regulation of Innate Resistance and Adaptive Immunity
9:00 a.m. - 11:00 a.m

Co-Chairs: Anil Shaker, NCI and Francesco M. Marincola, CC

The mechanisms by which the immune system can mediate tissue destruction and tumor regression depend on a complex interplay between the elements of the innate resistance and adaptive immunity. While considerable study has been focused on the innate shaping of the adaptive immune response, little attention has been paid to the adaptive influencing the innate system beyond well-characterized antibody-Fc receptor interactions. Some evidence has now accumulated to demonstrate that adaptive immunity might play an important role not only in the recruitment and activation of innate effector cells but also in dampening potentially damaging inflammation in an antigen-dependent manner. This mini-symposium will discuss recent advances in our understanding of the cross-regulation of adaptive and innate immune effector functions in cancer and other pathological conditions.

Program

Introduction
Anil Shanker, NCI

Presentation by FARE Award Winner
ABCG1 is a Negative Regulator of Pulmonary Host Defense
David Draper, NIEHS

The Immunologic Constant of Rejection
Francesco M Marincola, CC

Role of Interferon in Chronic Graft-versus-Host Disease
Frances T Hakim, NCI

Role of IL-1 in CD4 T Cell Effector Cytokine Production During M. Tuberculosis Infection
Katrin D Mayer, NIAID

Essential Role for NADPH Oxidase at the Crossroads of Innate and Adaptive Immunity
Sharon H Jackson, NIAID

CD4 T Cells Team Up with NK Cells and Tumor-associated Macrophages for Tumor Rejection
Ainhoa Perez-Diez, NIAID

CD8 T Cell Help for Innate Antitumor Immunity
Anil Shanker, NCI

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