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Home > Concurrent Symposia Sessions > Wnt Signaling in Development and Disease 

Concurrent Symposia Sessions

Wednesday, October 15, 2008
Natcher Conference Center
Symposia Session II
Balcony C

Wnt Signaling in Development and Disease 
10:30 a.m. - 12:30 a.m.

Chair: Terry Yamaguchi, NCI

Sponsored by the Wnt Working Group (this is an informal group of Wnt researchers from the NIH and Georgetown University)

Wnt signaling has a key role in many aspects of embryonic development and tissue homeostasis in the adult.  Alternatively, dysregulation of Wnt signaling contributes to a wide array of human diseases, including congenital malformations, cancer, metabolic, musculoskeletal, neurological and perhaps psychiatric disorders.  The canonical Wnt pathway up-regulates beta-catenin transcriptional activity to turn on a host of Wnt target genes, while non-canonical Wnt pathways regulate cell shape, motility and other properties through a variety of mechanisms.  In this minisymposium, investigators will describe their research concerning Wnt target genes in embryonic progenitor and cancer stem cells, non-canonical signaling in embryonic development, the identification of a novel regulator of Wnt signaling in kidney development, the potential role of cross-talk between Wnts and R-spondin proteins in mammary carcinogenesis and the use of an Ewing sarcoma family of tumor model system to study the mechanisms of Wnt-dependent neurite outgrowth.


Wnt Target Genes and the Regulation of Embryonic and Adult Cancer Stem/Progenitor Cells
Terry Yamaguchi, NCI

Non-canonical Wnt Signaling in Mouse Embryonic Development
Yingzi Yang, NHGRI 

A Novel Negative Regulator of the Wnt Pathway is Important for Kidney Development
Sean Lee, NIDDK

R-spondins and Wnts in Mammary Carcinogenesis
Robert Callahan, NCI

Wnt Stimulation of Neurite Outgrowth in an Ewing Tumor Cell Model System
Jeffrey Rubin, NCI

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