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Home > Concurrent Symposia Sessions > TGF-beta Superfamily Signaling in Health and Disease 

Concurrent Symposia Sessions

Wednesday, October 15, 2008
Natcher Conference Center
Symposia Session II
Balcony B

TGF-beta Superfamily Signaling in Health and Disease 
10:30 a.m. - 12:30 a.m.

Co-Chairs: Lalage Wakefield, NCI and Sushil G. Rane, NIDDK

The TGF-beta superfamily occupies a central position in the signaling circuits that control cell growth, differentiation, and death. Seminal work has resulted in a deeper appreciation of the integration of TGF-beta pathways into signaling networks at large and its disruption in human disorders. Although, TGF-beta remains elusive in terms of our complete understanding of its multifunctional modes of action, its potential utility as a therapeutic target is promising. This mini-symposium will discuss recent advances in our understanding of how TGF-beta superfamily signals are regulated and the global ramifications when these signals go awry in diseases such as diabetes, obesity and cancer.

Program:

Crossveinless-2 is a Short-range, Concentration-dependent, B iphasic Modulator of BMP Signaling in Drosophila
Mihaela Serpe, NICHD

Sending TGF-beta Signal to MAP kinase Pathways via a Familiar Road
Ying Zhang, NCI

Nexus of TGF-beta signaling with diabetes, obesity and the metabolic syndrome
Sushil G. Rane, NIDDK

New Tumor Suppressor Activities for TGF-beta in Breast Cancer: Effects on the Putative Cancer Stem and Progenitor Cells
Binwu Tang, NCI

Blockade of TGF-beta: Improvement of Tumor Immunity and Vaccine Efficacy
Masaki Terabe, NCI

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