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Home > Concurrent Symposia Sessions > Bridging the Gap between Research Discoveries and Clinical Evaluation

Concurrent Symposia Sessions

Tuesday, October 14, 2008
Natcher Conference Center
Symposia Session I
Conference Room F1/F2

Bridging the Gap between Research Discoveries and Clinical Evaluation
2:00 p.m. - 4:00 p.m.

Minkyung (Min) Song, NCI

Sponsored by the Translational Research Interest Group (TRIG)

In order to improve public health, the NIH Roadmap initiatives are accelerating the translation of scientific discoveries into practical applications.  Significant advancements in basic science research, molecular analysis technologies, bioinformatics, and validated procedures for collecting and storing high-quality clinical specimens have occurred in recent years.  Enormous amounts of data, information, and resources are available for physician scientists and basic research scientists to work together to correlate laboratory data with clinical observations.  Efforts are being made to improve and expedite the therapeutics development process by intelligently filling the gap between research discoveries and clinical practice, ultimately for benefit to patients.  The speakers in this symposium will discuss: translation of clinical research and epidemiological data on the use of non-steroidal anti-inflammatory drugs in Alzheimer’s disease back to the laboratory to improve preclinical models; application of laboratory discoveries to proof-of-concept clinical studies in kidney cancer and autoinflammatory diseases; a personalized genomics project featuring collaboration among NIH Institutes; and discovery and clinical evaluation of genetic and proteomic biomarkers of head and neck cancer for assessment of response to therapies, recurrence, and survival in collaboration with extramural cooperative groups.


COX Inhibition in Neuroinflammation: Neuroprotective or Neurotoxic? Lessons from Animal Models
Francesca Bosetti, NIA

The Genetic Basis of Kidney Cancer: Opportunity for Disease Specific Therapy
W. Marston Linehan, NCI

The Role of IL-1 in Neonatal Onset Multisystem Inflammatory Disease (NOMID) and Other Autoinflammatory Diseases
Raphaela Goldbach-Mansky, NIAMS

The ClinSeq Study: Developing a Model for Translational Genomics
Leslie Biesecker, NHGRI

The Nuclear Factor kappaB Transcriptome and Proteome in Targeted Therapy of Head and Neck Cancer
Carter Van Waes, NIDCD and NCI

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