Co-chaired by Sue Pierce, NIAID, and Larry Samelson, NCI
Sponsored by the NIAID, NCI and IIG

Conference Room E1/E2, Natcher Conference Center

The mechanisms by which cells respond to external stimuli provided through cell surface signaling receptors has been an area of intense investigation over the last decade.   Consequently, we now understand the biochemical nature of the cascades triggered by ligand binding to signaling receptors in several biological systems in great detail.   However, our knowledge of the temporal and spatial characteristics of the initiation and maintenance of signaling and activation at both the molecular and cellular levels lags far behind.   Over the last few years the application of new cutting edge imaging technologies has provided a view of cell signaling in live cells and of activation of cells in living tissues in real time.   Such studies are providing a wealth of new information about cell signaling and activation in a variety of biological systems.   This symposium will primarily focus on the use of new imaging technologies to understand signaling and cell activation in cells and tissues of the immune system.

Program:

Cbl-dependent Trafficking of TCR-induced Signaling Complexes
Lakshmi Balagopalan-Bhise, NCI

Visualizing Spatiotemporal Signaling Events toward Understanding the Signaling Network of Chemoattractant Sensing
Tian Jin, NIAID

Imaging B Cell Antigen Receptor Signaling in the Immunological Synapse with TIRF Microscopy
Pavel Tolar, NIAID

Intravital Visualization of B Cell Activation by Antigen-presenting Dendritic Cells in Lymph Nodes
Hai Qi, NIAID