Chaired by Daniel Appella, NIDDK

Conference Room F1/F2, Natcher Conference Center

This symposium features presentations by four established chemists in the intramural research program.  Dr. Kenneth Jacobson will discuss a series of molecules that mediate cardioprotective and anti-inflammatory functions.  Dr. John Inman will present a class of molecules that inhibit HIV by targeting a nucleocapsid protein.  Next, Dr. Victor Marquez will present a class of molecules that have antiviral activity against herpes simplex viruses and Kaposi's sarcoma-associated herpesvirus.  Finally, Dr. Kenner Rice will discuss a class of molecules that target corticotropin releasing hormone (CRH) receptors, and their role as research tools for PET imaging.   Each presentation demonstrates how a small, synthetic, drug-like molecule can be designed, and demonstrates the impact of such research in areas of biology and medicine.

Program:

Engineering of G Protein-coupled Purine Receptors and their Ligands
Kenneth A. Jacobson, NIDDK

Inactivation of HIV by 2-Mercaptobenzamide Thioesters through Covalent Attack on the Viral Nucleocapsid Protein, NCp7
John K. Inman, NIAID

The Investigation of a Conformational Concept Leads to the Discovery of a Potent and Selective Nucleoside Antiviral Agent against Kaposi Sarcoma
Victor E. Marquez, NCI

Design and Synthesis of Corticotropin Releasing Hormone (CRH) Antagonists as Drugs and Research Tools
Kenner C. Rice, NIDA