Chaired by Daniel Appella,
Conference Room F1/F2, Natcher Conference Center
This symposium features presentations by
four established chemists in the intramural research program. Dr.
Kenneth Jacobson will discuss a series of molecules that
mediate cardioprotective and anti-inflammatory functions. Dr.
John Inman will present a class of molecules that inhibit
HIV by targeting a nucleocapsid protein. Next, Dr.
Victor Marquez will present a class of molecules that have
antiviral activity against herpes simplex viruses and Kaposi's
sarcoma-associated herpesvirus. Finally, Dr. Kenner
Rice will discuss a class of molecules that target corticotropin
releasing hormone (CRH) receptors, and their role as research
tools for PET imaging. Each presentation demonstrates
how a small, synthetic, drug-like molecule can be designed,
and demonstrates the impact of such research in areas of
biology and medicine.
Engineering of G Protein-coupled Purine Receptors and
Kenneth A. Jacobson, NIDDK
Inactivation of HIV by 2-Mercaptobenzamide
Thioesters through Covalent Attack on the Viral Nucleocapsid
John K. Inman, NIAID
The Investigation of a Conformational
Concept Leads to the Discovery of a Potent and Selective
Nucleoside Antiviral Agent against Kaposi Sarcoma
Victor E. Marquez, NCI
Design and Synthesis of Corticotropin
Releasing Hormone (CRH) Antagonists as
Drugs and Research Tools
Kenner C. Rice, NIDA