Co-chaired by Douglas R. Lowy,
NCI, and Philip E. Castle, NCI
Balcony C, Natcher Conference Center
This session will highlight the enormous progress that
builds on the conclusion that infections by a group of
carcinogenic human papillomaviruses (HPVs) cause several
cancers, including virtually all cases of cervical cancer,
which is the second leading cause of cancer and cancer-related
mortality in women worldwide. Carcinogenic HPV is
also the etiologic agent of approximately 30% of oropharyngeal
cancer, as well as being linked to cancers of the oropharynx,
anus, vagina, and vulva. The knowledge of the central
role of HPV in cervical carcinogenesis, and delineation
of the natural history of HPV infection, is being translated
into new technologies for primary and secondary prevention. NIH
investigators are playing a leading role in these advances. Technologies
for primary prevention of HPV infection include the highly
efficacious virus-like particle (VLP) vaccines against
HPV16 and HPV18, the two HPV types that cause 70% of cervical
cancer and account for an even higher percentage of the
other cancers attributable to HPV, and the potential for
the development of potent vaginal microbicides that could
target the full spectrum of genital HPV infections. For
secondary prevention, HPV DNA testing has been shown to
be substantially more accurate and reproducible than the
Pap smear for detection of treatable precancerous and cancerous
cervical lesions. To achieve large reductions in
the global incidence of cervical cancer, these technologies
must now be adapted and/or made available to low-resource
and underserved populations of women, as more than 80%
of cervical cancer occurs in these populations.
Program:
HPV as the Necessary Cause of Cervical
Cancer: Implications for Primary and
Secondary Prevention
Philip E. Castle, NCI
HPV Vaccines to Prevent Cervical Cancer
John T. Schiller, NCI
Topical Microbicides Targeting HPV
Christopher B. Buck, NCI
HPV Vaccine Implementation and Cervical
Cancer Screening: Combining Personal
Health Information and Public Health Awareness
Carolyn Deal, NIAID
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