Chaired by Brian Murphy, NIAID

Main Auditorium, Natcher Conference Center

The role of a second protein encoded by the influenza A virus PB1 gene in the pathogenesis of the virus will be described.  An unexpected connection between the host's nervous system and the T-cell immune response to infection with influenza virus will be presented.  The development of live attenuated virus vaccines for pandemic influenza viruses and their testing in humans will be described.  A discussion of the genetics and evolution of influenza A viruses in the context of the recent determination of the sequence of the 1918 influenza A pandemic virus will be presented.

Program:

PB1-F2: A Novel Influenza A Virus Pathogenesis Factor
Jonathan Yewdell, NIAID

Nervous System Control of Anti-Influenza A Virus Immunity
Kristie Grebe, NIAID

Vaccines against Potential Pandemic Strains of Influenza
Kanta Subbarao, NIAID

Influenza Genetics and Evolution
Jeffery Taubenberger, NIAID