Chaired by Ann Dean, NIDDK

Balcony C, Natcher Conference Center

The maintenance of gene expression patterns which define the cellular phenotype during development and differentiation is highly dependent on chromatin structure and function.  Transcribed chromatin domains and silent neighborhoods are established by enzymatic complexes that modify chromatin and that are targeted to particular sites by DNA binding activators and repressors.  These modifications can be highly dynamic.  Emerging evidence suggests that higher order chromatin interactions also contribute to transcriptional outcome.  This symposium will bring together NIH scientists who have contributed to understanding chromatin domains, remodeling and epigenetic modification of chromatin, the dynamics of chromatin structure and the role of intra-nuclear localization of chromatin.

Program:

Chromatin Boundaries
Gary Felsenfeld, NIDDK         

Chaos and Order in the Living Cell
Gordon Hager, NCI

ATP-dependent Chromatin Remodeling Complexes and the Control of Gene Expression
Carl Wu, NCI 

Mechanisms of Higher-order Chromatin Assembly
Shiv Grewal, NCI

Chromatin Dynamics in Genome Regulation
Tom Misteli, NCI