Chaired by Xiaobing Chen, NINDS

Balcony A, Natcher Conference Center

EM tomography is an emerging new imaging technology that reveals three-dimensional structures of macromolecules and the organization of large macromolecular assemblies in cells.  It is playing an important role in bridging the gap between molecular biology and structural cell biology.  This session highlights the many exciting frontier research work accomplished with EM tomography fostered by the unique environment of NIH intramural program.  The topics include from virus structures, architecture of postsynaptic machinery at neuronal synapses, architecture of bacterial chemotactic machinery and structure of clathrin-coated vesicles, and new tomography techniques based on energy-filtered imaging and STEM.

Program:

Pleiomorphic Virus Structure
Alasdair Steven, NIAMS

Molecular Architecture of Postsynaptic Density
Thomas Reese, NINDS

Molecular and Spatial Architecture of the Bacterial Machinery for Chemotaxis
Sriram Subramaniam, NCI

Unconventional Modes for Electron Tomography of Biological Structures
Richard Leapman, ORS/OD

Tomographic Visualization of Clathrin-coated Vesicles
Bernard Heymann, NIAMS