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NIH Research Festival 2006
2006 NIH Research Festival

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October 17 - October 20
General Schedule of Events
Poster Sessions
Plenary Session
Concurrent Symposia
Job Fair for NIH Postdoctoral, Research, and Clinical Fellows
Special Exhibits on Resources for Intramural Research
TSA Research Festival Exhibit Show
Festival Food and Music Fair
Research Festival Committees
Past Research Festivals
Concurrent Symposia
  Wednesday, October 18, 2006
Natcher Auditorium

Benefits and Risks of ART in Preventing Mother-to-Child Transmission of HIV

10:30 am to 12:30 pm

Chaired by John Bucher, NIEHS

Balcony B, Natcher Conference Center

Zidovudine (ZDV; AZT) used in antiretroviral therapy (ART) alone or in combination with other drugs, is given to thousands of women to prevent mother-to-child transmission of HIV.   ZDV and some other effective antiretroviral drugs are nucleoside base analogues that can cause genetic changes and adverse health effects.  The NTP/NIEHS AIDS program uses rodent models to examine toxicities and develop biomarkers for use in humans undergoing ART.   This symposium will review the clinical benefits of ART in reducing mother-to-child transmission of HIV along with results of NTP/NIEHS studies of mitochondrial dysfunction, tumor induction, and biomarkers of genetic damage in rodents exposed in utero and postnatally to ZDV.  Finally, studies in infants born to HIV-infected women and exposed to ART will be discussed, with consideration given to implications of the collected findings for the long-term health of these children.


Antiviral Treatments to Prevent Mother-to-Child Transmission of HIV - A Success Story
Lynne Mofenson, NICHD 

Mitochondrial Diseases and Effects of ART on Mitochondrial DNA Replication
William Copeland, NIEHS

Changes in Cancer Genes in ZDV-induced Lung Tumors in Mice
Robert Sills, NIEHS

Biomarkers of Genetic Damage in Infants Exposed Prenatally to ZDV
Kristine Witt, NIEHS

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