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Research Festival Poster for 2004
2004 NIH Research Festival

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September 28 - October 1
General Schedule of Events
Keynote Address
Poster Sessions
Job Fair for NIH Postdoctoral, Research and Clinical Fellows
Special Exhibits on Resources for Intramural Research
TSA Research Festival Exhibit Show
Festival Food and Music Fair
Research Festival Committees
Symposia Session II - 4 Concurrent Symposia
  Tuesday, September 28, 2004
Natcher Conference Center

Mast Cell Signaling: Biological and Clinical Implications

2:30 p.m. - 4:30 p.m.

Co-Chaired by:
Michael A. Beaven, NHLBI
Juan Rivera, NIAMS

Balcony A , Natcher Conference Center

Mast cells are responsible for a variety of inflammatory allergic disorders that affect a large proportion of the population. Mast cells are activated via the multimeric immune receptor FceRI to initiate an array of intracellular signals that include early activation of Src kinases and Syk. Propagation and integration of these signals are achieved through the assembly of proteins into “signaling complexes” that lead to release of inflammatory mediators. The intriguing question is whether the information now available points to discrete therapeutic targets for treatment of allergic disease since current treatments are antisymptomatic rather than suppressive, with the exception of glucocorticoid therapy. In addition to acquired hypersensitivity to allergens, there is increasing evidence that mast cells play a role in innate immune responses, probably through toll-like receptors, against acute bacterial infections where the immunosuppressive actions of glucorticoids may be detrimental. Another key receptor on mast cells is Kit. The interactions of Kit with its ligand, stem cell factor, are critical for mast cell proliferation, survival, and biologic function. Mutations in Kit are associated with mastocytosis, a clonal disorder. Kit thus becomes a target for treatment of mastocytosis through identification of small molecular weight inhibitors of Kit tyrosine kinase activity. The speakers will address past and present developments in all of the above topics.


Mast Cells Take Their Toll
Henry Metzger, NIAMS

Uncovering New Complexities in FceRI Signaling with Possible Therapeutic Implications
Juan Rivera, NIAMS

The Essential Function of the Syk Protein Tyrosine Kinase in Signaling from FceRI
Reuben Siraganian, NIDCR

Suppression of FceRI-mediated Signals by Glucocorticoids and Potential Relevance to Therapy
Michael A. Beaven, NHLBI

Mutations in Kit Related to Mastocytosis and Mast Cell Signaling
Dean D. Metcalfe, NIAID

Modulation of Mast Cell Function in Innate immunity by Toll-like Receptors
Marianna Kulka, NIAID

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