Chaired by:
David Clark, NICHD

Balcony A, Natcher Conference Center

It is now generally recognized that chromatin structure plays a central role in gene regulation. The mechanisms by which cells control the inherently repressive nature of chromatin structure are becoming apparent: cells possess many different types of chromatin remodeling complexes. These can be grouped into two broad classes:(1) Chromatin-modifying enzymes that are typically subunits of large complexes. They catalyze various modifications of the histones, including acetylation and methylation; and(2) ATP-dependent chromatin remodeling machines. These use the free energy gained from ATP hydrolysis to move nucleosomes along DNA and to alter nucleosome conformation. This symposium will explore various aspects of chromatin remodeling and its links to epigenetics.

Program

Histone Variants and Cell Cycle Progression
Rohinton Kamakaka, NICHD

Building Blocks of a Chromatin Boundary
Miklos Gaszner, NIDDK

Sampling the Human Epigenome and High Throughput Mapping of Selected Regions
Bruce H. Howard, NICHD

ATP-dependent Chromatin Remodeling Complexes for Transcription
Carl Wu, NCI

Chromatin Remodeling and Nuclear Receptors - Old Friends and New Players
Gordon Hager, NCI