Wednesday,
October 11
10:30
am - 12:00 pm
Plenary Session 2 - Masur Auditorium, CC
Introduction
William
G. Stetler-Stevenson
Angiogenesis is the development of new blood vessels in response to pathologic stimuli. Vasculogenesis is the process of blood vessel formation during embryonic development. The angiogenic response can function to potentiate the progression of the initiating pathology, e.g. tumor growth and spread during cancer progression, pannus formation in rhuematoid arthritis, diabetic retinopathy. In other disease states the growth of new vessels can compensate for diminished physiologic function, e.g. neoangiogenesis in response to occlusive vascular disease, wound healing , etc. NIH investigators are exploring the molecular mechanisms involved in vasculogenesis, as well as the initiation and regulation of angiogenic response and in various disease processes, with the aim of developing new therapeutic strategies for both promoting and inhibiting angiogenesis. This session will provide a brief overview of ongoing, intramural investigations on these mechanism, therapeutic strategies and preclinical development of therapies aimed at regulation of angiogenesis and vascular formation.
Role
of Thymosin Beta 4 in Wound Healing
Hynda Kleinman, NIDR
Vasostatin,
an Angiogenesis Inhibitor that Inhibits Tumor Growth
Giovana
Tosato, CBER/FDA, and NCI
What
Guides Blood Vessel Formation during Development: Fishing
for Some Answers
Brant
Weinstein, NICHD
Antiangiogenic
Gene Therapy Approaches
Steve
Libutti, NCI
Angiogenesis
and Matrix Metalloproteinase Inhibitors:Preclinical and
Clinical Development
William
D. Figg, NCI
