NIH Research Festival
This study explores how prenatal exposure to particulate matter (PM) at different time windows during pregnancy impacts birthweight. We included 4,959 mother-infant pairs from the Upstate KIDS cohort born in New York State. Air pollution data were gathered from the EPA‚Äôs Community Multiscale Air Quality model and matched to home addresses at the census tract level. Birthweight and gestational age were gathered from vital records. We ran multiple linear regressions adjusting for maternal socio-demographics, traffic-related pollutants (O3, NO, and SO2), infant sex, plurality, and seasonality. Participants were exposed to relatively low levels of PM during pregnancy (median PM2.5: 8.81 ¬µg/m3, median PM10: 12.19 ¬µg/m3). Nevertheless, higher PM exposure across virtually all windows of pregnancy was associated with lower birthweight in unadjusted models (Model 1). After controlling for traffic co-pollutants (Model 2), PM2.5 and PM10 exposure around birth remained associated with lower birthweight, as did PM10 around the 1st trimester. However, further accounting for maternal and infant characteristics (Model 3) attenuated associations for the latter, while PM exposure around birth remained associated with lower birthweight (PM2.5: -42.89g; 95% CI: -69.22, -16.56; PM10: -35.40g; -61.67, -9.13). Prenatal exposure to PM may impact birthweight depending on other pollutants and specific windows of exposure. Prenatal exposure to PM during specific pregnancy windows, particularly later in pregnancy, requires further research. In addition, studies using more precise exposure assessment methods and looking at non-linear pollution interactions are required.
Scientific Focus Area: Epidemiology
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