NIH Research Festival
Mislocalization of Cse4 (CENP-A in mammals) leads to increased chromosome loss in budding yeast, human cells and xenograft mouse models. Overexpression and mislocalization of CENP-A to non-centromeric regions is observed in many cancers. This project analyzes the role of Cse4 and histone H4 interaction in the mislocalization of Cse4 to non-centromeric regions.
Scientific Focus Area: Genetics and Genomics
This page was last updated on Monday, September 25, 2023