Overexpression of Histone H4 Promotes Sumoylation of Cse4/CENP-A and Mislocalization to Noncentromeric Chromatin

– Poster session IV
2:30 – 4:00 p.m.

FAES Terrace

NCI

GEN-11

Authors

  • DN Bhatt
  • EM Pugacheva
  • LM Fedida
  • E Price
  • YJ Ji
  • D Loukinov
  • A Vostrov
  • VV Lobanenkov

Abstract

Mislocalization of Cse4 (CENP-A in mammals) leads to increased chromosome loss in budding yeast, human cells and xenograft mouse models. Overexpression and mislocalization of CENP-A to non-centromeric regions is observed in many cancers. This project analyzes the role of Cse4 and histone H4 interaction in the mislocalization of Cse4 to non-centromeric regions.

Scientific Focus Area: Genetics and Genomics

This page was last updated on Monday, September 25, 2023

2023 NIH Research Festival Agenda

2023 NIH Research Festival Poster Abstracts