NIH Research Festival
The tumor microenvironment (TME) consists of the surrounding blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix. It is important to investigate multiple aspects of the TME including identifying populations and cell-function interactions for prognosis and treatment of cancer. We hypothesize that using a multiple multiplex immunofluorescence panel we can characterize cells in normal and tumor in murine formalin-fixed paraffin-embedded tissues. We use multiplex immunofluorescence (IF) analysis to quantifying immune cell subsets, their functional state, and especially their spatial arrangement in the tumor microenvironment. In conclusion, several markers in our tumor microenvironment marker panel allowed for visualizing the spatial organization of the TME.
Scientific Focus Area: Cancer Biology
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