NIH Research Festival
Neurosurgeons assess syrinx reduction after surgery using MRI. Manual syrinx volume measurement is laborious. Semiautomated syrinx volume measurement is faster and may be accurate enough to detect surgically-related syrinx volume reductions reliably.
We analyzed pre- and post-operative SPGR axial MRI scans from syringomyelia patients using the manual Cavalieri method (CAV) (n=15) and two semiautomated methods: Spinal Cord Analysis Tool, SCAT (n=15) and 3DQI (n=8). Pre- and post-operative spinal cord and syrinx volumes were compared using the paired t-test.
Syrinx volumes (mm3) were significantly larger before (pre) than after surgery (post) across all methods. CAV syrinx volume was: pre, 4515 mm3 ¬± 3720, post, 1109 mm3 ¬± 1469 (p=0.0004). SCAT syrinx volume was, pre, 4584 mm3 ¬± 3826, post, 1064 mm3 ¬± 1465 (p=0.0014), and 3DQI was, pre, 3540 mm3 ¬± 2666, post, 751 mm3 ¬± 810 (p=0.008). CAV detected fluid in irregular, discontinuous, and narrow syringes. Spinal cord volumes were CAV, pre, 13342 mm3 ¬± 6198, post 8721 mm3 ¬± 3389 (p=0.0002). SCAT, pre, 11290 mm3 ¬± 5727, post, 7530 mm3 ¬± 3210 (p=0.0009), and 3DQI, pre, 11888 mm3 ¬± 6108, post, 7873 mm3 ¬± 3785 (p=0.031). Mean spinal cord volumes measured before operation (pre) differed significantly: CAV and SCAT (p=0.003), paired t-test); CAV and 3DQI (p=0.01). Likewise, mean spinal cord volumes after operation (post) also differed significantly (CAV vs. SCAT, p=6.5E-05; CAV vs. 3DQI, p=0.01).
The semiautomated methods, SCAT and 3DQI, provided acceptably-precise syrinx volume measurements in less time than the manual method.
Scientific Focus Area: Clinical Research
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