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Association between pre-diagnostic circulating 25-hydroxyvitamin D and cancer survival

Thursday, September 14, 2017 — Poster Session III

12:00 p.m. – 1:30 p.m.
FAES Terrace
NCI
EPIG-4

Authors

  • SJ Weinstein
  • AM Mondul
  • K Yu
  • TM Layne
  • CC Abnet
  • ND Freedman
  • RZ Stolzenberg-Solomon
  • U LIm
  • MH Gail
  • D Albanes

Abstract

Vitamin D has been associated with increased overall cancer survival in some, but not all, studies, and few investigations have prospectively examined specific cancer sites. We examined pre-diagnostic serum 25-hydroxyvitamin D [25(OH)D], the accepted biomarker of vitamin D status, in relation to overall and site-specific cancer survival in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of Finnish men. The analysis included 4,616 men with measured serum 25(OH)D who were diagnosed with cancer during 22 years of follow-up. Of these, 2,884 died of their cancer and 1,732 died of other causes or survived. Multivariable-adjusted proportional hazard regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between pre-diagnostic 25(OH)D and overall and site-specific cancer survival. Serum 25(OH)D was significantly lower among cases who subsequently died from their malignancy compared with those who did not (medians 34.7 vs. 36.5 nmol/L, respectively; p=0.01). Higher 25(OH)D was associated with lower overall cancer mortality (HR=0.76, 95% CI 0.67-0.85 for highest vs. lowest quintile, p-trend

Category: Epidemiology