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K-Ras4B-RASSF5 Activation Mechanism: How does K-Ras4B Regulate the Hippo pathway and YAP1 Expression through RASSF5?

Friday, September 16, 2016 — Poster Session IV

12:00 p.m. – 1:30 p.m.
FAES Terrace
NCI
COMPBIO-5

Authors

  • T Liao
  • H Jang
  • D Fushman
  • R Nussinov

Abstract

Ras proteins transduce signals between cell surface receptors and intracellular signaling cascades. K-Ras4B is particularly frequently mutated in lung, colorectal, and pancreatic cancers, and importantly, its drug resistance is often accompanied by overexpressed YAP1. RASSF5 is an effector which has a critical interactions with K-Ras4B and with MST1/2 in the Hippo Pathway - inhibit MST1/2 resulting in YAP1 overexpression. We propose to figure out the complex of K-Ras4B-RASSF5 mechanism and to reveal how K-Ras4B regulates the Hippo pathway through RASSF5.

Category: Computational Biology